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Merck began trials of the HMG-CoA reductase inhibitor lovastatin in 1980, and won a historic approval in 1987-- showing the medication produced robust reductions in LDL levels

IGF-1 LR3s non-selective receptor activation stimulates collagen synthesis and chondrocyte proliferation in cartilage, tendons, and ligaments not just skeletal muscle

GSH could also be converted to oxidized GSH (GSSG) via various glutathione peroxidases (GPX) in this process (Figure 3)