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The glutathione peptide of one inhibitor, termed productive binding, occupies the G-subsite with multiple interactions similar to those observed for other glutathione S-transferases, while the glutathione backbone of the second inhibitor, termed unproductive binding, exhibits only weak interactions mediated by two polar contacts

Studies have confirmed that phloretin has a protective effect on hepatotoxicity and endothelial dysfunction induced by a high choline diet in mice (91)

conducted a systematic review and meta-analysis to investigate the impact of acetylL-carnitine (ALC) on depressive symptoms

Additionally, both agents influence lipid metabolism, albeit differently