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This finding highlights a fundamental distinction that must be applied when interpreting the preclinical literature as a whole: the majority of studies reporting positive outcomes employed a preventive or co-treatment paradigm, in which the drug was administered prior to or concurrently with pathological induction

They are sensitive to hydration status and can give misleading readings

The SELECT trial demonstrated cardiovascular benefit in patients with established heart disease, showing approximately 20% reduction in major adverse cardiovascular events

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