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According to the literature, says Christina OConnor, RD, with Pendulum Therapeutics, [berberine] should be taken approximately 30 minutes before meals to minimize blood sugar spikes and prevent any gastrointestinal side effects. She adds that the maximum dose is 900-1500 milligrams per day, with the doses split up three to four times throughout the day

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Demeneix, B., Vandenberg, L

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Its a big fat no from me

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Cagrilintide combination strategies Cagrilintide was explicitly designed to be combined with other compounds

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