tirzepatide drops vs injection Curious about the differences between today's most popular GLP-1 medications? Here's your quick guide to semaglutide, tirzepatide, and retatrutide — three powerful tools on the journey toward weight loss, metabolic balance, and Tirzepatide vs. Semaglutide: Which Weight

The medication's primary gastrointestinal side effectsparticularly nausea, vomiting, and diarrheacan lead to dehydration if fluid intake is inadequate or losses are not appropriately replaced

Data extraction and synthesis From the eligible studies, detailed variables were extracted to facilitate a structured narrative comparison

All semaglutide formulations are expected to have similar side effects

Clinical Trial Results STEP Trials (Semaglutide) The STEP program studied semaglutide 2.4 mg weekly in overweight/obese adults: STEP 1 : 16.9% average weight loss over 68 weeks vs 2.4% placebo STEP 2 (T2D patients): 9.6% weight loss STEP 3 (with behavioral therapy): 16.0% weight loss STEP 5 (2-year data): 15.2% sustained weight loss SURMOUNT Trials (Tirzepatide) The SURMOUNT program studied tirzepatide at 5mg, 10mg, and 15mg weekly: SURMOUNT-1 : 20.9% average weight loss at 15mg over 72 weeks vs 3.1% placebo SURMOUNT-2 (T2D patients): 14.7% at 15mg SURMOUNT-3 (with lifestyle intervention): 26.6% at highest dose SURMOUNT-4 (maintenance): continued weight loss vs weight regain on placebo Head-to-Head No large head-to-head trial has directly compared them at optimal doses for weight loss