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One of the most significant of these is the activation of SIRT1, often called a longevity gene. SIRT1 helps manage insulin sensitivity and supports healthier blood sugar regulation, which is fundamental for sustained energy and preventing the metabolic strain that can lead to weight gain

In this study of 545 patients with type 2 diabetes, TIR showed a strong negative correlation with HbA1c, indicating its potential as both a short-term and long-term diabetes management marker