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Jump to: How much weight do people lose on each | How retatrutide and Mounjaro work differently | Side effects compared | What happens if you stop taking the medication | Cost and access in the UK | Cardiovascular and long-term safety | Muscle mass and body composition | Switching considerations | Who should consider which | Frequently asked questions | Take home message | Second Natures Mounjaro programme | References Retatrutide has produced larger weight loss than Mounjaro in trials so far, with an average weight loss of up to 28.7% at 68 weeks in retatrutides TRIUMPH-4 trial, compared with up to 22.5% at 72 weeks in Mounjaros SURMOUNT-1 trial
Table 2: GLP-1 Side Effect Survival Guide Note: If side effects are severe, persistent, or concerning, it is essential to contact a healthcare provider immediately
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A 2,700person realworld study presented at the 2025 European Congress on Obesity showed an average of semaglutide
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