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Bile can also harm the intestine, cross the blood-brain barrier, and trigger neurological and systemic inflammation77

It involves a coordinated system comprising four key enzymes encoded by the Bhc gene cluster: the PLP-dependent aminotransferase (BhcA), serine/threonine dehydratase (BhcB), -hydroxyaspartate aldolase (BhcC), ornithine cyclodeaminase (BhcD), and along with an IclR-family transcriptional regulator