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2022 (NEJM Phase 1 trial)

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However, analyses of single-agent interventions found that neither exenatide nor liraglutide significantly affected the risk of DKA in individuals with T1DM, indicating insufficient evidence to support a definitive protective or harmful effect at the individual drug level

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the next generation added GIP (the meal-response pathway)

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thiol oxidation sensitivity flagged from known chemical properties of the GSH/GSSG redox couple

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