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in 2023 conducted a double-blind, randomized, placebo-controlled trial that examined the oral administration of collagen dipeptides (1650 mg per day for 12 weeks) in 100 women in Korea (3060 years of age) and compared the placebo group ( n = 46) with the treatment group ( n = 54) in terms of skin hydration, elasticity, desquamation, and wrinkling [42]

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10.3389/fopht.2023.1310226 172

Its minimal tetrapeptide structure and regulatory classification make it particularly valuable for mechanistic investigations involving genomic and epigenetic signaling networks