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Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: TRIUMPH clinical development program rationale and design
The primary end points for part one were (1) resolution of steatohepatitis without worsening of liver fibrosis, and (2) reduction in liver fibrosis without worsening of steatohepatitis Primary outcome: Results In patients with MASH and moderate or advanced liver fibrosis, once-weekly semaglutide at a dose of 2.4 mg improved liver histologic results
Fix: Shoot for 8 00010 000 steps/day and schedule a weekly movement audit. If energy is low, add a maintenance-calorie refeed day, then reassess
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