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Fourth, MR requires stringent assumptions, i.e., the genetic variants are associated with the exposure, no confounders of the associations of the genetic variants with the outcomes exist, and the genetic variants are not associated with the outcomes other than via affecting the relevant exposure (no pleiotropy) [17]

Side effects are rare, and most people tolerate it well

Melanin is responsible for the formation of dark spots, and glutathione acts as an intelligent guardian, neutralizing free radicals and brightening the skin from within

This paradigm explains the high prevalence of OA in non-weight-bearing joints (e.g., hands) among obese individuals, a finding that cannot be attributed to mechanical load alone