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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default
Pilitsi, E
The proper ratio is a critical first step
Verify coverage policies before performing the procedure, as some insurers require prior authorization for certain diagnoses or frequency limitations
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