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Long-term considerations and staying on treatment What happens when you stop taking these medications
First Week to First Month: Expected Changes and Weight Loss Timeline During week 1-2, appetite suppression becomes the dominant sensation, and many patients naturally reduce calorie intake by 30-40% without conscious effort
Expect minimal loss in the first month, followed by an average of 1-2 pounds weekly for the first 3-6 months, potentially leading to 15-20% total body weight loss by months 9-15
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Available evidence from diabetes and obesity trials demonstrates substantial weight regain after discontinuation of GLP-1 RAs, reaching pre-treatment levels in some cohorts within 12-18 months of cessation, with accompanying deterioration in cardiometabolic parameters [72]
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