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Melanotan-1 activates melanocortin-1 receptors (MC1R) on melanocytes, triggering a transcriptional cascade that increases melanin synthesis for 35 days after the peptide itself has cleared
In conclusion, we found that ALC significantly reduced SREBP2 and HMGCR expression, leading to decreased de novo cholesterol synthesis, lower serum cholesterol levels in HCD-fed mice, and attenuated atherosclerotic progression
[PubMed] Melkonian EA, Asuka E, Schury MP
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