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Failure of UPS surveillance promotes the accumulation of misfolded proteins, proteotoxic aggregates, fibrosis, and ultimately contractile dysfunction and heart failure

While calorie balance still matters, diet quality, protein intake, metabolic health, and consistency play a larger role in long-term success

However, a cavity on the capsid surface at an inter-protomer interface, where we previously reported extra electron density 7 , has recently been identified as potentially druggable, with micro-molar binding for a benzene-sulfonamide derivative 8

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