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A healthy lifestyle is the basis to optimise health outcomes regardless of WL increased levels of physical activity have multiple health benefits including improvement of body composition, physical function and cardiorespiratory fitness, and a balanced Mediterranean diet may be associated with cardiovascular benefits [105]

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Although Novo Nordisk holds trademarks for Ozempic and Wegovy, it is unclear whether advertising compounded semaglutide products, even including a reference to Ozempic and Wegovy in the ad, truly creates any consumer confusionand it likely will remain unclear until there is a case that is fully litigated. Disclosure: Armin Ghiam has represented defendants against claims asserted by Novo Nordisk

13 demonstrated inhibition of food intake after intracerebroventricular (ICV) as well as direct hypothalamic administration of GLP-1 in rats