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The addition of glucagon receptor agonism introduces a third axis: increased energy expenditure, enhanced hepatic fat oxidation, and PCSK9-mediated reduction in LDL cholesterol
However, a recent study that utilized the single-cell RNA-seq technology provided further evidence regarding the heterogeneous POMC cell populations within the ARC and revealed that the chemogenetic activation of POMC GLP-1R-expressing neurons could remarkably suppress feeding while activation of POMC Leptin receptor-expressing neurons cannot [27]
Cch s dng: Lu : Ph n mang thai v cho con b nn hi kin t bc s trc khi s dng
These pathways facilitate the production of energy in the form of adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH), both of which are essential for numerous cellular reactions (34, 35)
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