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Mice homozygous for the spontaneous ( Lepr db ) mutation develop severe obesity starting at 34 weeks of age, accompanied by overnutrition-related complications including postprandial hyperglycemia, and eventually pancreatic cell atrophy and hypoinsulinemia
Emma F, Hoff WV, Hohenfellner K, Topaloglu R, Greco M, Ariceta G, Bettini C, Bockenhauer D, Veys K, Pape L, Hulton S, Collin S, Ozaltin F, Servais A, Deschenes G, Novo R, Bertholet-Thomas A, Oh J, Cornelissen E, Janssen M, Haffner D, Rava L, Antignac C, Devuyst O, Niaudet P, Levtchenko E (2021) An international cohort study spanning five decades assessed outcomes of nephropathic cystinosis
Czlonkowska, A
HRT addresses the upstream hormonal withdrawal
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