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Demyelination protocols For LPC demyelination, adult (812 weeks) C57BL/6 mice were anesthetized with ketamine/xylazine, the skull exposed, and a small hole drilled 1 mm rostral and 1 mm lateral of bregma
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Mutat Res- Fundam Mol Mech Mutagen
Component-Level Trial Findings CJC-1295 (without DAC, modified GRF 1-29) Phase 1 and Phase 2 work described: Dose-dependent GH elevation (2-10x baseline at studied doses, PMID 16352683) IGF-1 elevation of 1.5-3x baseline at 1-2 weeks Mild facial flushing post-injection in some participants No serious adverse events at studied doses CJC-1295 with DAC The DAC-modified version covalently binds to albumin, extending half-life to 5-8 days (PMID 16352683)
