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Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection

Complementing these findings, a one-year randomized controlled trial by Villareal and colleagues demonstrated that obese older adults who achieved a 10.1% weight loss through combined diet and exercise experienced significant decreases in hip BMDincluding the trochanter and femoral neckwhile spine and whole-body BMD were preserved

They are also responsible for the development of male secondary sexual characteristics (androgenic effect) ( Uncontrolled use of substances from the AAS group for non-medical purposes is associated with a high risk of adverse effects on the liver and the reproductive, musculoskeletal, cardiovascular, and central nervous systems