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This effect helps with fullness, but it can also worsen nausea, bloating, or reflux in some people, especially after large evening meals
In addition, satiety signals from the liver and gastrointestinal tract signal through the vagus nerve to the nucleus of the solitary tract (NTS, for the Latin term nucleus tractus solitarii ) to cause meal termination, and in combination with the hypothalamus, integrate the various signals to determine the feeding response
Modern glucose-lowering therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), align well with this approach owing to their benefits in glycemic control, weight loss, and reduced cardiovascular and kidney risks [12,13,14,15]
Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R
