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Funding We acknowledge financial support from the National Institutes of Health (NIH) through grant R35GM138217 (HV)
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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications
Insulin resistance, chronic stress, poor sleep, and certain medications (antidepressants, antipsychotics, corticosteroids) can counteract appetite suppression
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