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Changes in eating and diet Avoiding previously enjoyed foods Avoiding entire food groups - carbohydrates, protein Abrupt changes in diet/new diets Eating large portions of food rapidly Cooking calorie-rich foods for others but not eating them Needing to control the exact ingredients in meals Using child-sized bowls or cutlery Changes in exercise and movement Having to exercise in order to earn food Significant guilt or anxiety if unable to exercise Inability to sit still, always standing Exercising despite injuries Changes in behavior Avoiding eating in front of others Using the bathroom immediately after eating Social withdrawal - avoiding social situations where food is involved Wearing baggy clothing Weighing oneself daily Changes in mood Increased irritability without a clear cause Increased anxiety and depression Common physical symptoms Fainting or lightheadedness Gastrointestinal symptoms (i.e., abdominal pain, nausea) Loss of menses in females Unexplained weight loss Types of Eating Disorders Anorexia nervosa involves concerns about body shape and an intense fear of weight gain that drive extreme food restriction

The step-by-step protocol to reduce injection site reactions Step 1: Optimize injection technique

10.1038/s41467-020-20154-8 42 DaiZ.HuangY.SadeeW.BlowerP

George Bell, MD