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The American Diabetes Association's Standards of Care acknowledge the ongoing uncertainty, noting that while pancreatitis has been reported with GLP-1 receptor agonist use, a definitive causal relationship has not been established

Clinicians must also avoid intravenous administration in the presence of severe sino-atrial, atrioventricular, or intraventricular conduction block in the absence of functional pacemaker support, as well as in classic Adams-Stokes or Wolff-Parkinson-White syndromes, where suppression of accessory pathways may paradoxically precipitate fatal arrhythmias

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