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Figure 6 From our RNAseq analysis, we noted that many of the upregulated genes in the glutathione biosynthesis pathway (including Gclc and Gclm ) are canonical targets of the transcription factor NRF2 (24, 53, 54)

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Chronic kidney disease basics, Centers for Disease Control and Prevention 6 easy ways to prevent kidney stones, National Kidney Foundation Inflammation and oxidative stress in chronic kidney diseasethe potential therapeutic role of minerals, vitamins and plant-derived metabolites, International Journal of Molecular Science (2020) Vitamins and minerals in CKD, National Kidney Foundation Vitamin D and chronic kidney disease, The Korean Journal of Internal Medicine (2014) Vitamin D deficiency, StatPearls Iron-deficiency anemia in CKD: A narrative review for the kidney care team, Kidney Medicine (2023) Vitamin B12 and chronic kidney disease, Vitamins and Hormones (2022) Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677CT polymorphism in MTHFR, Journal of Hypertension (2010) Thiamin, National Institutes of Health High blood pressure and CKD, National Kidney Foundation Vitamin C, National Institutes of Health Calcium and calcium supplements: achieving the right balance, Mayo Clinic (2022) Kidney failure risk factors, National Kidney Foundation Systematic review of nutrition supplements in chronic kidney diseases: A GRADE approach, Nutrients (2021) N-acetylcysteine for chronic kidney disease: a systematic review and meta-analysis, American Journal of Translational Research (2021) Chronic kidney disease (CKD), National Institute of Diabetes and Digestive and Kidney Diseases Dietary supplements, Federal Food and Drug Administration Federal GMPs for dietary supplements, Natural Products Association Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice