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This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants

In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)

3) Angiotensin Receptor Blockers (ARBs, -sartan) Alternative to ACE inhibitors with similar cardiovascular and renal benefits

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