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This can lead to immune suppression or dysregulationleaving the body more susceptible to infections and autoimmunity

Common symptoms include: Dry, itchy skin Hair thinning or excessive hair shedding Fatigue and weakness Numbness or tingling in hands and feet Difficulty concentrating or brain fog If left unaddressed, a deficiency can lead to more serious issues, such as anemia or neurological complications

As in differentiating some other cases of oral mucosal melanin hyperpigmentations one from another, on clinical and histological grounds alone it is impossible to make a positive diagnosis of tobacco-related melanosis