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The weakest part of the argument is that no clinical trial has ever tested this specific combination, the additive effect of levocarnitine on top of tirzepatide substantial metabolic impact may be negligible, and the cost premium is not clearly justified by the expected benefit
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A 2021 review of 13 studies reached a similar conclusion, finding that GLP-1 receptor agonist treatment caused between 11.2 to 13.6 pounds of weight loss over periods ranging from 12 to 68 weeks
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