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21 Antioxidants and Oxidative Stress To protect human cells and organ systems against free radicals, a complex antioxidant system exists

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5.1.2 Effects on pancreatic -cell glucagon release In addition to their insulinotropic effects on -cells, both GIP and GLP-1 play a role in regulating glucagon secretion of pancreatic -cells, with GIP increasing and GLP-1 suppressing glucagon secretion, both in a glucose-dependent manner