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Three key findings result from our study: (1) pwIIH treated with GLP-1-RAs lose significantly more weight than pwIIH electing for UCWM only, (2) treatment with GLP-1-RAs is associated with favorable headache outcomes, and (3) treatment with GLP-1-RAs is not associated with any severe adverse events in IIH, and thus presents a safe treatment option for weight management in pwIIH

Research on Combined Approaches A 2025 meta-analysis of 33 randomized controlled trials, involving 12,028 participants, revealed that adding lifestyle changes to GLP-1 therapy resulted in an additional 7.13 kg (15.7 lbs) of weight loss , a reduction in waist circumference by 5.74 cm , a drop in systolic blood pressure by 3.99 mmHg , and a decrease in fasting blood glucose by 6.51 mg/dL

The body is beginning to adjust to the semaglutide

Published 2022 Nov 23