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Severe or concerning symptoms warrant medical attention and discontinuation of use

These hormonal shifts may partially explain reported improvements in erectile function and overall sexual health among individuals practicing IF [58]

However, subgroup analyses from the TOPCAT clinical trial indicated that patients enrolled from the Americas, where adherence to therapy was higher, experienced notably higher rates of hyperkalemia compared to those from Russia and Georgiasupporting the hypothesis that increased exposure to spironolactone may have contributed to the regional differences in adverse event profiles [56]