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Velazquez said new drugs will use different mechanisms of action, in the same way that medications for high blood pressure can work differently in the body
Found's model supports patients seeking structured behavioral change alongside pharmacotherapy
In people with obesity, 36 weeks of orforglipron (doses ranging from 12 to 45 mg in a phase 2 trial) resulted in a dose-dependent WL up to 14.7% compared to 2.3% with placebo, with concomitant improvement in cardiometabolic risk factors (Table 2) [25]
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