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Statistically significant reduced incidence seen across multiple large cohorts For this analysis, the researchers looked at health records from 111,646 women ages 45 to 80 with a body mass index (BMI) of 25 or above (the overweight threshold) who had breast imaging and a documented outcome in the Penn Medicine EHR between January 2022 and June 2025

Timing considerations Morning and evening applications are common for twice-daily protocols

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