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For researchers who have switched from one to the other, the guides on switching from tirzepatide to semaglutide and the semaglutide to tirzepatide conversion chart are useful references for the transition period

American Journal of Physiology-Heart and Circulatory Physiology, 303(6), H703H711

When to talk to your healthcare provider Contact your prescribing physician or healthcare provider if constipation persists despite fiber supplementation and complementary strategies for more than 3 weeks, if you experience severe abdominal pain, if you notice blood in your stool, if you develop symptoms of bowel obstruction (vomiting, inability to pass gas, severe abdominal distension), or if constipation is significantly impacting your quality of life or making you consider discontinuing your GLP-1 medication

Reduced glutathione is the active form