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Moreover, oral BPC-157 has a low bioavailability and does not usually have a direct effect on tissues outside the gastrointestinal tract (e.g., tendons and nerves)

Journal of Cosmetic Dermatology, 2015

However, based on the research to date, researchers will want to consider the following guidelines when when administering these peptides: Subcutaneous and intramuscular injections are considered more effective due to enhanced bioavailability , but using BPC-157 + TB-500 nasal spray could have certain advantages depending on the therapeutic objective and study design

Its believed it either works by activating other repair cells that can help tendons or ligaments or making the human growth factor receptor on these cells more sensitive (6)