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A 2025 real-world analysis confirmed that extending the titration phase by 4-8 weeks (staying at each dose longer before escalating) significantly reduced GI side effects without meaningfully affecting 52-week weight loss outcomes

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Researchers also noted that some loss of lean body mass occurs during significant weight reduction, regardless of treatment strategy

It's crucial to document when you started using Ozempic, when you first experienced side effects, and any medical treatment received for those side effects