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In a small-scale study of older patients with T2DM and mild cognitive impairment (n = 250), DPP4i-based glucose-lowering therapy was associated with a slower deterioration of cognitive function, mainly attentional and executive functions, compared to the sulfonylurea-based glucose-lowering therapy over a 2-year follow-up (Odds ratio: 0.88, 95% CI 0.450.99, p = 0.03) ( versus metformin group over 6 months in patients without AD: 0.95 2.17 versus 2.50 3.03) ( et al
Individuals with a BMI of 30 or above, or 27 or above with weight-related comorbidities, under qualified medical supervision
At the halfway point of roughly six months, most of that progress was already well underway, with patients typically showing 12% to 18% reductions in body weight
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