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SALB administration in Glp1r OB-KORD RD mice had no effect on glycaemia nor insulin levels during OGTT compared with controls (Fig

In pancreatic cells, activation of these G proteincoupled receptors primarily signals through pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function

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Long-term use may be required to maintain weight loss, which has cost and ongoing commitment implications