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Its relevance comes from its combined GLP-1, GIP, and glucagon receptor activity profile, making it useful for laboratory models examining how multiple incretin and metabolic signaling pathways interact within the same experimental framework
It can be found in both oxidized and reduced forms
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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38
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