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Common gastrointestinal adverse effects associated with semaglutide include: Nausea (reported in up to 44% of patients on Wegovy, 20% on Ozempic, and 15% on Rybelsus) [2] [4] Vomiting Diarrhea Constipation Abdominal pain or discomfort Dyspepsia These effects are typically dose-dependent and most pronounced during the initial titration phase, with higher rates observed at weight management doses compared to diabetes doses
Ongoing research is examining the effects of exercise, including resistance training in combination with GLP-1 RA therapy (ClinicalTrials.gov: NCT05786521, NCT04122716)
Nausea: 28% Diarrhea: 24% Constipation: 21% Vomiting: 17% Discontinuation due to side effects: 11.2% Lower doses showed proportionally fewer side effects
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