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Less severe but still problematic gastrointestinal reactions warrant dose holds and systematic side effect management
In addition to these widely used AOMs, Exenatide, one of the earliest GLP-1 RAs approved by the FDA and EMA for T2DM management, is not indicated for weight management but remains clinically relevant, particularly in older adults with comorbid obesity and T2DM, given its long-term clinical experience and established tolerability profile [26,27,28]
Figure 8: Atherosclerosis causes artery thickening (tunica intima hyperplasia) and clot formation by platelets
de Bruin, A
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