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Yes, many people stack them because they work through different biological mechanisms
Others involve quality issues at specific compounding pharmacies
These benefits are now also evident in people with obesity at high CVD risk (or with known vascular disease) but without T2D, as shown by the favorable effects of semaglutide in the Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) clinical trial 36
Thats meaningful for supplements but smaller than the effect sizes seen with many prescription options
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