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Its primary functions include stimulating insulin release from the pancreas, suppressing glucagon (a hormone that raises blood sugar), slowing gastric emptying, and signalling satiety (fullness) to the brain

If genetic testing reveals you have a variant associated with lower GLP1R sensitivity, tirzepatide's dual action may compensate by activating your more responsive GIP pathway

But mostly, Goldman suspects, people with taste aversions on semaglutide will need to work through the emotional adjustment of suddenly disliking universally agreed-upon delicious foods