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Non-English studies were excluded
Contraindications include known hypersensitivity to any component of the injection (including cobalt hypersensitivity), a history of severe reactions to thiamine/pyridoxine/cobalamin injections, and Lebers hereditary optic neuropathy (for B12-containing products)
Copper(II) ions are essential for the activity of lysyl oxidase, the enzyme that catalyzes the covalent cross-linking of collagen and elastin fibers
Evidence suggests mixed outcomes depending on treatment duration and individual skin factors
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