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Emerging evidence highlights a range of contributing factors, including reduced mechanical loading, increased bone marrow adiposity, hormonal and endocrine alterations, nutritional deficiencies, and disruptions in energy metabolism
Genuine adult GHD can be diagnosed via stimulation testing and, where confirmed, treated with licensed recombinant human growth hormone (somatropin) under specialist supervision, in accordance with NICE technology appraisal TA64
Evidence against a universal class effect However, one case provides a compelling counterexample
doi: 10.3390/ijms23073797 60 Otulak-KozieK.KozieE.TrederK.KirlyL
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