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A pragmatic way forward is to (i) use Bayesian inference to express uncertainty in clinically interpretable probabilities, and (ii) use data-driven phenotyping (including ML-enabled clustering where appropriate) to describe heterogeneity in treatment response

Value of both clinical trials and real-world data studies Both the SURMOUNT-5 clinical trial and Truveta Researchs real-world evidence study reinforce the same key trend: tirzepatide-based medications consistently outperform semaglutide-based medications for weight loss in patients with overweight or obesity