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The patients most likely to show a divergent psychiatric response to GLP-1 therapy those with comorbid SUD, prior mood episode history, or active anhedonia at baseline are exactly the patients who get excluded for psychiatric instability. The result is a Phase 3 dataset that proves efficacy in a population cleaner than anyone sitting in an actual psychiatric clinic

Asian J Pharm Res

This focus on rhythm over intensity is central to how we guide therapy decisions