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Charugulla (2021) Efficacy and safety comparison of combination of 0.04% tretinoin microspheres plus 1% clindamycin versus their monotherapy in patients with acne vulgaris: a phase 3, randomized, double-blind study, Journal of Dermatological Treatment, 32:8, 925-933, DOI: 10.1080/09546634.2020.1720579 Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ

Intravenous glutathione studies report headache, dizziness, and localized injection reactions in fewer than 3% of cases

PubMed laboratory research record [PMID: 17959533] PubMed record related to this compound for laboratory literature review

And if you're drinking for several hours, you're likely not drinking much water to top it up either