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The NO pathway plays an important role in intestinal smooth muscle function and mucosal protection, and disruption of this system is associated with certain inflammatory bowel presentations
Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide
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